NFL Predictions - Week 21
Access our data-driven free NFL picks for the 2026 season. Below you will find our top-rated predictions against the spread and moneyline value plays. Looking for a bigger payout? Combine these bets in our Daily NFL Parlay.
How We Generate Expert NFL Picks
The NFL is a game of margins. At Picksmuse, we look beyond the win/loss column. Our NFL prediction model utilizes advanced metrics to find the edge:
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DVOA & EPA/Play:Â We analyze “Expected Points Added” per play to judge how efficient an offense really is, regardless of the final score.
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Trenches Matchups:Â Football is won at the line of scrimmage. We compare Offensive Line vs. Defensive Line win rates to predict which QB will be under pressure.
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Weather Impact:Â We monitor wind speed and precipitation for every outdoor game, as these factors drastically affect passing yards and field goal accuracy.
Types of Football Picks We Offer
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NFL Picks Against the Spread (ATS):Â Our flagship offering. We predict which team will cover the number set by Vegas.
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NFL Player Props:Â Using projection data, we find value on individual stats. Popular picks include “Anytime Touchdown Scorer” and “Quarterback Passing Yards Over/Under.”
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Super Bowl Predictions:Â From the coin toss to the MVP, we cover every angle of the biggest game of the year.