ATL @ CIN
MIN @ PIT
SD @ WSH
LAA @ TB
CHC @ STL
SF @ COL
PHI @ LAD

Chicago Cubs vs St. Louis Cardinals MLB Predictions – 29.05.26

Last Updated: May 29, 2026 1:50 AM
Friday, 29 May 2026 CHC -143
Chicago Cubs

Chicago Cubs

31-26
S. Imanaga
VS 7:15 PM
St. Louis Cardinals

St. Louis Cardinals

29-25
K. Leahy

Match Winner

St. Louis Cardinals

Total Runs

Over 8

Tale of the Tape

Chicago Cubs CHC
Stat Comparison
STL St. Louis Cardinals
4.65 R/G 4.35
7.91 H/G 8.02
.238 BA .238
4.22 ERA 4.22

Key Matchup: Starting Pitchers

VS
S. Imanaga

S. Imanaga

4.04 ERA
4-5
K. Leahy

K. Leahy

4.44 ERA
5-3

Detailed Analysis

Who will win today? Chicago Cubs vs St. Louis Cardinals MLB Preview

The St. Louis Cardinals will take this game because they are returning home with a chip on their shoulder after a narrow loss, while the Chicago Cubs are prone to a letdown after a high-scoring blowout win. Busch Stadium is a massive yard that punishes fly-ball pitchers, and the Cardinals dugout has the grit needed to exploit a tired Chicago Cubs bullpen.

The Starter Showdown: S. Imanaga vs K. Leahy

S. Imanaga enters with a 4.04 ERA, but the eye test shows he has been fading late in his recent starts. When the lineup turns over for the third time, he struggles to keep the ball in the park, which is a dangerous recipe against veteran hitters.

On the other side, K. Leahy and his 4.44 ERA might not look lights out on paper, but he has a knack for inducing weak contact. If he can avoid shelling out free passes, his sinker should keep the Chicago Cubs bats quiet in the early frames.

Offensive Trends & Lineup Depth

The Chicago Cubs are coming off a 7-2 win, but travel fatigue often catches up to a team moving cities after a big offensive night. Expect their bats to go cold as they adjust to the deeper dimensions of the St. Louis outfield.

The St. Louis Cardinals only put up a .180 AVG in their last outing, meaning they are due for a breakout. They will likely utilize small ball and aggressive base running to put pressure on S. Imanaga during high-leverage counts.

Looking for more action? See our More MLB Picks.

Our Final Verdict

The St. Louis Cardinals have the home-field advantage and a lineup that rarely stays quiet two days in a row. With the Chicago Cubs potentially gassed from travel, the Redbirds should find plenty of gaps to drive in runs.

Pick to Win: St. Louis Cardinals

Total Runs (Over/Under): over (Line: 8)

Last 5 Games: CHC

Form:
WWLLL
VS @PIT
W 7-2
VS @PIT
W 10-4
VS @PIT
L 1-12
VS @PIT
L 1-2
VS vs HOU
L 5-8

Last 5 Games: STL

Form:
LLLLL
VS @MIL
L 1-2
VS @MIL
L 0-6
VS @MIL
L 1-5
VS @CIN
L 0-0
VS @CIN
L 6-7

Written by Matt Dorsey

5 YEARS EXPERIENCE

Matt Dorsey turned his obsession with sports into a career five years ago, and he hasn't looked back. By combining a fan's passion with a veteran’s analytical eye, Matt provides reliable insights for the NBA, NHL, and NFL. He knows you’re looking for more than just a pick; you’re looking for a reason to trust the play. That’s why his work is always transparent, researched, and rooted in five years of proven results.

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