Chicago White Sox vs Chicago Cubs Prediction 05/18/2025 | MLB

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This Sunday, the two Chicago teams will face each other again, but they are in completely different situations. The Cubs are leading their division, while the White Sox are one of the worst teams in MLB.

Chicago White Sox vs Chicago Cubs: Cubs -1.5

The CWS continue to be one of the weakest teams in MLB, with an offense that averages just 3.38 runs scored per game (the third-worst figure in the league) and pitchers who have a collective ERA of 4.15. The Cubs took advantage of these shortcomings on Friday and won 3-13, and they will surely know how to capitalize on it again, given that they have the third-best offense in the league with 5.71 runs scored per game, and they will have Collin Rea as their starter, who has allowed 2 or fewer runs in five of his six starts. With the Cubs at home and being far superior, we expect them to achieve a comfortable victory.

Injuries for Chicago White Sox:

A. Benintendi Out.

K. Lee Out.

F. Ellard Out.

M. Pérez Out.

Injuries for Chicago Cubs:

I. Happ Out.

T. Miller Out.

E. Morgan Out.

S. Imanaga Out.

J. Steele Out.

Chicago White Sox vs Chicago Cubs: Over 7.5

The powerful Cubs offense should not have many problems doing damage to Jonathan Cannon, the CWS pitcher here, despite having decent performances recently. Also, although the White Sox are quite deficient in attack, they could at least do the same as the first game of this series and produce some runs, so we expect a game with the offenses as protagonists and many points.

Chicago White Sox vs Chicago Cubs Prediction

The difference between both teams is very large and obvious, so we expect the Cubs, who will be the home team, to confirm their superiority and take a victory by at least two runs, and we will have a score with many points.

The odds provided are an estimate, please check before you bet.