Prediction St. Louis Cardinals vs Baltimore Orioles 05.28.25

We’re looking at a matchup between the St. Louis Cardinals (31-24), currently sitting comfortably above .500, and the Baltimore Orioles (19-35), who are struggling to stay competitive. This game, scheduled for May 28th, 2025, at 6:35 PM in Oriole Park at Camden Yards, pits two teams with vastly different trajectories against each other.

The Cardinals are a solid all-around team. Their batting average of .259 (5th in the league) shows decent pop in their lineup, translating to 4.65 runs per game. Their pitching staff, boasting an ERA of 3.72, is a key strength. They’re getting the job done, limiting opposing offenses to 8.62 hits per game. They’re a well-balanced team capable of putting up runs and stifling opponents.

The Orioles, on the other hand, are facing a tougher season. Their batting average sits at a mediocre .236 (22nd in the league), resulting in a meager 3.8 runs per game. Their pitching staff is struggling, with a concerning ERA of 5.45, allowing 7.72 hits per game. Their bullpen, with only 9 saves, adds to their defensive woes. They need a significant turnaround to climb the standings.

On the mound, we have a compelling contrast. For the Cardinals, Miles Mikolas (4-2, ERA 3.51) brings experience and consistency. For the Orioles, Cole Povich (1-3, ERA 4.86) will be looking to turn things around. Mikolas’s lower ERA and proven track record give him a clear advantage in this matchup.

Given the Cardinals’ superior offense and pitching, and the Orioles’ struggles in both areas, I’m predicting a Cardinals victory. Considering the Orioles’ high run-allowed average, and the Cardinals’ ability to score runs, I’m also going over the 8.5 total runs line.